This is caused by poor grammar on the viewers part. Nightbot sees this as someone trying to bypass a URL spam filter and gives them a little tough love.
For the most part, the person in your screenshots uses “me” in the wrong grammatical way which Nightbot sees as a URL like .me and so on.
Grammar Example: “My grandmother and I” not “Me and my grandmother”
So to prevent this, a viewer would need to use proper grammar to avoid the false positives.